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TOXIC EFFECTS OF PROLONGED ENDOSULFAN EXPOSURE ON SOME BLOOD PARAMETERS IN ALBINO RAT

By: . Das1, Kawser Pervin, A. K. Roy, Z. Ferdousi, A. K. Saha

Key Words: Endosulfan, prolonged exposure, haematology, haemochemical parameters, albino rat

JLES-Vol-5-No-P-29-32, December 2010

Abstract

Endosulfan is a worldwide used synthetic insecticide that has an important role on management of pests in agriculture. The present work was undertaken to determine the effect of endosulfan on the haematological and haemochemical parameters of albino rats. Rats were feed with 5 mg/kg body weight endosulfan in mixed food stuff for 42 days. The studies were conducted on sexually matured male rats covering five groups of animals with control. Total counts of erythrocytes and haemoglobin were decreased and leucocytes were increased in treated group. Differential counts of leucocytes showed significant increase in basophils and monocytes. The levels of serum glucose, urea, creatinine and bilirubin increased significantly, suggesting that the synthetic insecticide had remarkable toxic effects on the haematological and biochemical parameters in the experimental animals.

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Table 3. Effect of endosulfan on glucose, urea, creatinine and bilirubin level in sera of Albino rats.

 

Days Exposure Glucose (mg/dl) Urea (mg/dl) Creatinine (mg/dl) Bilirubin (mg/dl)
 

15

 Treatment 1 132.61 ± 1.283 32.486 ± 0.336 0.78 ± 0.06 0.328 ± 0.036
Control 1 103.08 ± 8.21 31.7 ± 0.672 0.51 ± 0.21 0.286 ± 0.022
 

21

 Treatment 2 134.326 ± 1.982 33.5 ± 0.753 1.08 ± 0.139 0.37 ± 0.02
Control 2 111.29 ± 0.365 33.043 ± 0.924 0.74 ± 0.016 0.308 ± 0.022
 

28

 Treatment 3 145.09 ± 1.96 36.536 ± 0.388 1.35 ± 0.259 0.59* ± 0.230
Control 3 110.39 ± 0.792 33.48 ± 0.421 0.79 ± 0.02 0.286 ± 0.022
 

35

 Treatment 4 149.995** ± 4.160 38.023*±0.416 1.71** ± 0.086 0.44* ± 0.11
Control 4 110.205 ± 0.618 33.176 ± 0.735 0.88 ± 0.05 0.308 ± 0.022
 

42

 Treatment 5 149.993** ± 2.943 38.936** ± 0.346 1.73** ± 0.096 1.014** ± 0.045
Control 5 110.76 ± 0.91 33.65 ± 0.742 0.98 ± 0.87 0.308 ± 0.022

Values are Mean±S. E.; *p<0.05,**p<0.01, ***p<0.001 Vs Control, Students t-test

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Manuscript received on 16 May 2010 and revised on 24 November 2010

. Das1, Kawser Pervin, A. K. Roy, Z. Ferdousi, A. K. Saha

TOXIC EFFECTS OF PROLONGED ENDOSULFAN EXPOSURE ON SOME BLOOD PARAMETERS IN ALBINO RAT

JLES-Vol-5-No-P-29-32, December 2010

https://jlescience.com/les-publish/toxic-effects-of-prolonged-endosulfan-exposure-on-some-blood-parameters-in-albino-rat/

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